If your very sensitive to the things people do, say and perceive, how do you handle it?

Learn to accept negative words from others and move on. Not all people in the world are going to be nice, but rather rude. However, you have to understand that people who like to criticize or belittle others do it because they are insecure about themselves. Don't them influence you and put you in a bad mood. You are the only one that can allow others to influence how you feel; you have a choice. I know it may be hard, but fighting back just puts you back in their world, and that is the last thing you need, because you need to worry about living in your own.